Symposium D focuses on the synthesis, characterization, and performance (both in vitro and in vivo) of coatings and modified surfaces designed for biomedical applications (biomaterials, bioimplants, biosensors, general health care, etc.). The symposium will be devoted to create a platform, a friendly hub, to promote some research discussions between material scientists, coating performers, and clinicians. Papers are solicited in areas related to: bioactive and biocompatible coatings for implants (orthopedic, dental, spinal, etc.), cardio-vascular stents, drug delivery and biosensing; hydroxyapatite coatings; biomimetic and bio-inspired coatings; anti-bacterial, anti-biofouling and eluting coatings; blood-compatible coatings; electrospun coatings; biofunctionalization of materials surfaces such as tissue engineering scaffolds by wet chemical and plasma methods; cell-surface interactions; bio-lubrication and bio-tribology; and processing and characterization of biomaterial surfaces. Concerning the interactions between the coating and the medium, some investigations were dedicated to study the corrosion degradation of the substrate. Moreover, some opening fields are focused on the effect of the coating on the biological behavior, as cells growth, cells adhesion, etc. Some contributions in the fields of retrieval implant analysis, the release of metal ions/particles, smart/intelligent surfaces and potential clinical concerns will be also considered. A new key-interest is about 3D printing. Additive manufacturing requires most of the time some surface coatings in order to promote osseointegration and more generally biocompatibility. The D symposium will have a look at this new area.
D1. Surface Coating and Surface Modification in Biological Environments
This session is dedicated to coatings as well as surface modifications for use in biomedical applications in order to improve performance characteristics or to add additional functions to an implant or surgical instrument. The functionalities of these coatings/surface modifications should focus on the improvement of one or more attributes such biocompatibility, cell proliferation and growth, suppression of restenosis, thrombus formation, antimicrobial behavior and metallic ion release, load-bearing prostheses, corrosion resistance, wear resistance, etc. under in vitro and in vivo conditions.
D1 Invited Speakers:
- Asimina Kiourti, The Ohio State University, USA, “Wireless Monitoring of the Implants and Coatings: Challenges and Opportunities in Health Care”
- Sriram Ravidran, UIC College of Dentistry, USA, “Progress in the Application of Regenerative Medicine for the Implant Coatings”
D2. Bio-corrosion, Bio-tribology and Bio-Tribocorrosion-Additive Manufacturing Impact
Metallurgical materials are essential components of medical devices used to restore biological function, detect or respond to physiological or external stimuli, or modulate the response of cells at interfaces. This session seeks to explore clinical applications and physiological responses to material systems used for tissue regeneration, implantable sensors, and smart drug delivery, among others. Fabrication and testing of these materials using additive manufacturing technologies are of particular interest. Research is solicited that evaluates biological reactions to implant surface coatings as well as methods of depositing coating particles of varying size and composition. Release of molecules or particles from surfaces, either intentionally or due to wear and corrosion processes is also an area of interest.
D2 Invited Speaker:
- Mobin Salasi, Curtin University, Western Australia, “Tribocorrosion Lifetime of Additive Manufacturing Materials. What are the Key Parameters and Strategies about Materials Optimization?”
D3. Biointerfaces: Improving the Cell Adhesion and Avoiding Bacteria. What Kinds of Coatings/Surfaces Should be Used?
Interaction between cells and biomaterials occur via the surface characteristics of the material, which include their topography, chemistry, mechanical properties or surface energy. These interactions trigger desired or undesired processes. For example, they can induce signaling pathways to regulate cell adhesion, migration, proliferation and differentiation into specific phenotypes desirable for the application. However, they might also promote excessive adhesion of microorganisms forming biofilms that can lead to signiﬁcant health risks. Such interactions are greatly determined by the initial protein adsorption that occurs in a shorter time scale. Understanding of all these interaction processes and their correlation with the surface properties is key knowledge that will allow us to design novel surfaces or coatings to promote specific biological responses, i.e. design bioactive surfaces.
The use of coatings and/or engineering surfaces is of great advantage for this purpose, since it allows us to keep the mechanical properties of the bulk materials and also the topographical features while designing the chemical surface to prevent chronic inflammatory responses, promote a faster osseointegration or prevent bacterial adhesion, as examples.
D3 Invited Speaker:
- Laszlo Sajti, AIT Austrian Institute of Technology GmbH, Austria, “Advanced Materials for Implant Applications”
DP Coatings for Biomedical and Healthcare Applications (Symposium D) Poster Session